@font-face{font-family:Source Sans 3;src:url('/fonts/source-sans-3-latin.woff2') format('woff2');font-weight:400 700;font-style:normal;font-display:swap}
@font-face{font-family:Source Serif 4;src:url('/fonts/source-serif-4-latin.woff2') format('woff2');font-weight:400 600;font-style:normal;font-display:swap}
body.reader{--ink:#162f3d;--paper:#f8f7f3;--surface:#fff;--muted:#53646d;--line:#dce2df;--accent:#006b64;--font-sans:'Source Sans 3',sans-serif;--font-body:'Source Sans 3',sans-serif;--font-serif:'Source Serif 4',Georgia,serif;--font-display:var(--font-serif);--font-mono:'Source Sans 3',sans-serif;background:var(--paper)!important;color:#233843;font:17px/1.65 var(--font-sans);margin:0;overflow-x:clip}
.reader *{box-sizing:border-box}.reader [hidden]{display:none!important}.reader a{color:var(--accent)}.reader button,.reader input,.reader select{font:inherit}.reader button{cursor:pointer}.reader button:disabled{cursor:default}.reader :focus-visible{outline:3px solid #00897e!important;outline-offset:4px}.reader [id]{scroll-margin-top:100px}.reader .reader-skip{position:fixed;left:16px;top:-100px;z-index:2000;padding:12px 20px;background:#fff}.reader .reader-skip:focus{top:12px}
.reader-rail{position:fixed;inset:0 auto 0 0;width:252px;background:#102b38;color:#d6e4e5;z-index:60;display:flex;flex-direction:column;border-right:1px solid #23424d;padding:32px 20px 20px;overflow-y:auto}.reader-brand{display:flex;gap:12px;align-items:center;color:#fff!important;text-decoration:none;margin:0 8px 37px}.reader-brand-mark{border:1px solid #719c9a;display:grid;place-items:center;width:38px;height:42px;font:25px var(--font-serif);color:#b7dace}.reader-brand strong{font:23px var(--font-serif);letter-spacing:-.5px}.reader-brand small{display:block;text-transform:uppercase;font:12px/1.5 var(--font-sans);letter-spacing:2px;color:#aac1c5;margin-top:4px}.rail-label{font-size:12px;letter-spacing:2px;text-transform:uppercase;color:#9db6bd;margin:12px 14px}.reader-chapters{display:grid;gap:3px}.reader-chapters a{display:flex;align-items:center;gap:13px;min-height:46px;padding:10px 13px;border-radius:5px;text-decoration:none;color:#d6e4e5;font-size:15px;border-left:2px solid transparent}.reader-chapters a:hover{background:#1b3b48}.reader-chapters a[aria-current=page]{background:#244b51;color:#fff;border-left-color:#a8d7be}.reader-chapters .chapter-number{font-size:12px;color:#93b4b6;width:19px;font-variant-numeric:tabular-nums}.reader-rail-bottom{margin-top:auto;padding:32px 12px 0;font-size:12px;color:#a8c0c5}.reader-rail-bottom a{color:#dce9e8;display:inline-block;padding:6px 0}.reader-rail-bottom p{margin:10px 0;line-height:1.6}
.reader-shell{margin-left:252px;min-width:0}.reader-topbar{height:76px;position:sticky;top:0;z-index:40;border-bottom:1px solid var(--line);background:#f8f7f3f5;backdrop-filter:blur(12px);display:flex;align-items:center;justify-content:space-between;padding:0 clamp(24px,4vw,64px);gap:20px}.reader-topbar-label{font-size:13px;color:var(--muted);white-space:nowrap}.reader-topbar-label strong{color:var(--ink);font-weight:600}.reader-search-launch{display:flex;align-items:center;gap:12px;border:1px solid #cbd6d1;border-radius:6px;min-height:44px;background:var(--surface);padding:8px 14px;color:var(--muted);font-size:14px;min-width:270px;text-align:left}.reader-search-launch kbd{margin-left:auto;border:1px solid var(--line);padding:0 5px;border-radius:3px;color:var(--muted);font:12px var(--font-sans)}.reader-mobile-menu{display:none}.reader-progress{position:absolute;bottom:-1px;left:0;height:2px;background:var(--accent);width:0;transition:width .15s linear}.reader-preview-label{font-size:12px;letter-spacing:1px;text-transform:uppercase;color:#52676a;border:1px solid #c7d4cc;padding:3px 8px;border-radius:3px}
.reader-main{max-width:1540px;margin:0 auto;padding:36px clamp(24px,4vw,64px) 80px;min-width:0}.reader-breadcrumb{font-size:13px;color:var(--muted);display:flex;align-items:center;gap:10px;margin-bottom:28px}.reader-breadcrumb a{text-decoration:none}.reader-masthead{display:grid;grid-template-columns:minmax(0,1fr) minmax(260px,38%);gap:40px;align-items:center;padding-bottom:36px;border-bottom:1px solid var(--line);margin-bottom:20px}.reader-eyebrow{text-transform:uppercase;letter-spacing:2px;font-size:12px;color:var(--accent);font-weight:700;margin-bottom:14px}.reader-title{font:400 clamp(36px,3.5vw,56px)/1.12 var(--font-serif)!important;letter-spacing:-1.5px;color:var(--ink);margin:0 0 20px!important;max-width:21ch}.reader-deck{font-size:18px;line-height:1.65;color:#53646d;max-width:61ch;margin:0 0 22px}.reader-byline{display:flex;gap:12px;align-items:center;font-size:12px;line-height:1.5;color:var(--muted)}.reader-byline-mark{width:32px;height:32px;display:grid;place-items:center;border:1px solid #cadbd0;border-radius:50%;color:var(--accent);font-family:var(--font-serif);font-size:13px}.reader-byline strong{display:block;color:var(--ink);font-weight:600}.reader-hero{margin:0;border-radius:8px;overflow:hidden;align-self:stretch;background:#e4ebe6;position:relative;min-height:240px}.reader-hero img{width:100%;height:100%;max-height:360px;min-height:240px;object-fit:cover;display:block}.reader-hero button{position:absolute;bottom:12px;right:12px;background:#fffffff2;color:var(--ink);border:0;border-radius:5px;padding:8px 12px;font-size:12px;min-height:44px}.reader-hero figcaption{position:absolute;width:1px;height:1px;overflow:hidden;clip-path:inset(50%)}.reader-masthead.no-image{grid-template-columns:1fr}.reader-masthead.no-image .reader-title{max-width:29ch}.reader-masthead.no-image .reader-deck{max-width:78ch}
.reader-tools{display:flex;gap:8px;align-items:center;flex-wrap:wrap;padding:0 0 20px;border-bottom:1px solid var(--line);margin-bottom:24px}.reader-tool{display:inline-flex;align-items:center;justify-content:center;gap:7px;min-height:44px;border:1px solid #cbd6d1;background:transparent;padding:8px 13px;border-radius:5px;color:var(--ink);font-size:13px;font-weight:500}.reader-tool:hover,.reader-tool[aria-pressed=true]{background:#e5f2ec;border-color:#9cbfb1}.reader-time{margin-left:auto;font-size:12px;color:var(--muted)}.reader-governance{border:1px solid var(--line);border-left:3px solid #a5bdb0;border-radius:4px;background:#f0f3ee;margin:0 0 36px;font-size:13px;line-height:1.65}.reader-governance summary{padding:12px 16px;cursor:pointer;font-weight:600;color:#354c50}.reader-governance .governance-notice{display:block!important;margin:0!important;padding:0 16px 16px!important;border:0!important;background:none!important;box-shadow:none!important;max-width:none!important;font-size:13px!important}.reader-governance .governance-notice:before{display:none!important}.reader-governance .governance-notice strong{display:none}.reader-governance p{margin:0!important}
.reader-grid{display:grid;grid-template-columns:minmax(0,1fr) 190px;gap:48px;align-items:start}.reader-article{min-width:0}.reader-outline{position:sticky;top:106px;max-height:calc(100vh - 140px);overflow:auto;padding-left:18px;border-left:1px solid var(--line)}.reader-outline h2{font:600 12px var(--font-sans);text-transform:uppercase;letter-spacing:1.7px;color:var(--muted);margin:0 0 17px}.reader-outline nav{display:grid;gap:2px}.reader-outline a{font-size:12px;line-height:1.45;text-decoration:none;color:#53646d;padding:7px 0 7px 10px;border-left:2px solid transparent}.reader-outline a:hover,.reader-outline a[aria-current=true]{color:var(--accent);border-left-color:var(--accent)}.reader-outline .reader-outline-footer{font-size:12px;line-height:1.6;color:var(--muted);padding-top:20px;margin-top:15px;border-top:1px solid var(--line)}
.reader .reading-content{font-size:17px;line-height:1.75;color:#233843;min-width:0}.reader .reading-content *{font-family:var(--font-sans)!important}.reader .reading-content h2,.reader .reading-content h3,.reader .reading-content .section-title{font-family:var(--font-serif)!important}.reader .reading-content .page-layout{display:block!important;max-width:none!important;margin:0!important;padding:0!important;grid-template-columns:1fr!important}.reader .reading-content .main-content,.reader .reading-content .prose-page,.reader .reading-content .prose-body{max-width:none!important;width:auto!important;margin:0!important;padding:0!important;background:none!important;border:0!important;box-shadow:none!important;min-width:0}.reader .reading-content .section,.reader .reading-content .sc-card{margin:0 0 36px!important;padding:0 0 36px!important;background:none!important;border:0!important;border-radius:0!important;box-shadow:none!important;border-bottom:1px solid var(--line)!important;opacity:1!important;transform:none!important}.reader .reading-content .section-title,.reader .reading-content h2{font-size:32px!important;line-height:1.22!important;letter-spacing:-.5px!important;color:var(--ink)!important;font-weight:400!important;margin:8px 0 14px!important}.reader .reading-content .section-title em,.reader .reading-content h2 em{font-family:var(--font-serif)!important;color:var(--accent)!important;font-style:normal}.reader .reading-content h3{font-size:25px!important;line-height:1.3!important;letter-spacing:-.2px!important;color:var(--ink)!important}.reader .reading-content h4{color:var(--ink)!important}.reader .reading-content p,.reader .reading-content .body-text,.reader .reading-content .tc-text,.reader .reading-content .pc-text,.reader .reading-content .sc-text,.reader .reading-content .callout-text{font-size:17px!important;line-height:1.75!important;color:#354b56!important}.reader .reading-content .section-num,.reader .reading-content .section-subtitle{font-family:var(--font-sans)!important;color:var(--muted)!important}.reader .reading-content .section-num{font-size:12px!important;letter-spacing:1.8px!important}.reader .reading-content .section-subtitle{font-size:14px!important;margin-bottom:24px!important}.reader .reading-content .section-rule,.reader .reading-content .breadcrumb-bar{display:none!important}.reader .reading-content .trial-card,.reader .reading-content .drug-profile,.reader .reading-content .pipeline-card,.reader .reading-content .rec-card,.reader .reading-content .callout,.reader .reading-content .alert-card{border:1px solid var(--line)!important;border-radius:7px!important;background:var(--surface)!important;box-shadow:none!important;overflow:hidden!important;margin:22px 0!important}.reader .reading-content .tc-banner,.reader .reading-content .dp-banner,.reader .reading-content .gh-banner{height:3px!important;background:#6e9b89!important}.reader .reading-content .tc-header,.reader .reading-content .pc-header,.reader .reading-content .dp-header{background:var(--surface)!important;padding:24px!important}.reader .reading-content .tc-name,.reader .reading-content .pc-name,.reader .reading-content .dp-name{font-size:24px!important;color:var(--ink)!important;font-weight:600!important}.reader .reading-content .tc-full-name,.reader .reading-content .pc-subtitle,.reader .reading-content .tc-meta-item{color:var(--muted)!important;font-size:13px!important}.reader .reading-content .tc-body,.reader .reading-content .pc-body,.reader .reading-content .dp-body{padding:24px!important;border-top:1px solid var(--line)!important}.reader .reading-content .tc-meta-row{flex-wrap:wrap!important;gap:10px 20px!important}.reader .reading-content .tc-tags{flex-wrap:wrap!important}.reader .reading-content .tc-verdict-val{font-size:28px!important}.reader .reading-content .outcomes-row{gap:12px!important}.reader .reading-content .outcome-box{border-radius:5px!important;background:#f1f5f0!important;box-shadow:none!important;border:0!important;padding:18px!important}.reader .reading-content .ob-val{font-size:26px!important;color:var(--accent)!important}.reader .reading-content .ob-label{font-size:12px!important;letter-spacing:1px!important}.reader .reading-content .stats-band{background:#e9efe8!important;border-radius:6px!important;color:var(--ink)!important;box-shadow:none!important;padding:24px!important;margin:22px 0!important}.reader .reading-content .stat-num{color:var(--ink)!important;font-family:var(--font-serif)!important;font-size:38px!important}.reader .reading-content .stat-label{color:#53646d!important;font-size:12px!important}.reader .reading-content .callout{padding:20px!important;background:#eff4ed!important}.reader .reading-content .callout-label{color:var(--accent)!important}.reader .reading-content .callout-icon{display:none!important}.reader .reading-content table{border-collapse:collapse!important;font-size:14px!important;width:100%!important;margin:0!important;background:#fff!important}.reader .reading-content th{font-size:12px!important;text-transform:uppercase;letter-spacing:.6px;background:#edf2ec!important;color:var(--ink)!important;text-align:left!important;white-space:normal!important}.reader .reading-content td,.reader .reading-content th{padding:13px 16px!important;border-bottom:1px solid #e4e9e2!important;vertical-align:top!important;line-height:1.55!important}.reader .reading-content tr:hover td{background:#f5f8f3}.reader .reading-content .table-wrap,.reader .reading-content .table-container{overflow:auto!important;border:1px solid var(--line)!important;border-radius:6px!important;max-width:100%}.reader .reading-content .footnote{font-size:12px!important;color:var(--muted)!important}.reader .reading-content .anim{opacity:1!important;transform:none!important;animation:none!important}
.reader .reading-content .figure-atlas{max-width:none!important;padding:0!important;margin:48px 0!important}.reader .reading-content .atlas-header{margin-bottom:24px!important}.reader .reading-content .atlas-kicker{color:var(--accent)!important}.reader .reading-content .atlas-figures{display:grid!important;grid-template-columns:1fr!important;gap:28px!important}.reader .reading-content .atlas-figure,.reader .reading-content .page-hero-figure{border:1px solid var(--line)!important;border-radius:7px!important;background:#fff!important;box-shadow:none!important;margin:0!important;overflow:hidden!important}.reader .reading-content .atlas-figure-header{padding:18px 24px!important;background:#f0f3ed!important}.reader .reading-content .atlas-figure-title{font-size:18px!important;line-height:1.4!important}.reader .reading-content .atlas-image-wrap{padding:14px!important;background:#fff!important}.reader .reading-content .atlas-image-wrap img,.reader .reading-content .diagram-box img{max-height:none!important;width:100%!important;height:auto!important;object-fit:contain!important;cursor:zoom-in;border-radius:4px!important}.reader .reading-content .atlas-description{padding:24px!important;background:#fff!important;display:block!important}.reader .reading-content .atlas-summary,.reader .reading-content .atlas-explanation-text{font-size:15px!important;line-height:1.7!important}.reader .reading-content .atlas-description-block+.atlas-description-block{border-top:1px solid var(--line);margin-top:18px;padding-top:18px}.reader .reading-content .atlas-explanation-label{font-size:12px!important;color:var(--accent)!important;letter-spacing:1.3px!important}.reader .reading-content .faq-section{padding:0!important;margin-top:44px!important}.reader .reading-content .faq-item{background:#fff!important;border:1px solid var(--line)!important;border-radius:5px!important;margin:10px 0!important;padding:0!important}.reader .reading-content .faq-item summary{padding:18px 22px!important;cursor:pointer;font-size:16px!important;font-weight:600}.reader .reading-content .faq-item p{padding:0 22px 20px!important;margin:0!important}.reader .reading-content .home-luxe{padding:0!important}.reader .reading-content .home-hero,.reader .reading-content .hero{min-height:0!important}.reader .reading-content svg{max-width:100%}.reader .reading-content .diagram-box{overflow:auto!important}
.reader-section-actions{display:flex;gap:8px;margin:14px 0 18px}.reader-section-actions button{font:12px var(--font-sans)!important;background:transparent;border:1px solid #cdd9d0;color:var(--muted);border-radius:4px;padding:6px 10px;min-height:44px}.reader-section-actions button[aria-pressed=true]{background:#e5f2ec;color:var(--accent)}.reader-disclosure{margin-top:16px;background:#f3f6f0;border:1px solid #d5dfd5;border-radius:4px;padding:9px 14px;color:var(--accent);font-size:13px;min-height:44px}.reader-table-tools{display:flex;align-items:center;justify-content:space-between;gap:12px;flex-wrap:wrap;margin:20px 0 8px;font-size:12px;color:var(--muted)}.reader-table-tools input{border:1px solid #b9ccc1;border-radius:4px;padding:9px 12px;min-height:44px;max-width:100%;background:#fff;width:250px;font-size:14px}.reader-table-region{overflow:auto;max-width:100%;border:1px solid var(--line);border-radius:5px}.reader-sort{background:none;border:0;color:inherit;text-align:left;font:inherit;letter-spacing:inherit;text-transform:inherit;min-height:44px;padding:0 16px 0 0;position:relative;width:100%}.reader-sort:after{content:'↕';position:absolute;right:0;opacity:.65}.reader [aria-sort=ascending] .reader-sort:after{content:'↑'}.reader [aria-sort=descending] .reader-sort:after{content:'↓'}.reader-large .reading-content p,.reader-large .reading-content .body-text,.reader-large .reading-content .tc-text,.reader-large .reading-content .pc-text,.reader-large .reading-content .sc-text{font-size:20px!important}.reader-focus .reader-outline{display:none}.reader-focus .reader-grid{grid-template-columns:1fr;max-width:850px;margin:auto}.reader-focus .reader-rail{transform:translateX(-100%)}.reader-focus .reader-shell{margin-left:0}.reader-focus .reader-main{max-width:1150px}.reader-footer{border-top:1px solid var(--line);padding:32px clamp(24px,4vw,64px);background:#efefe8;display:flex;gap:30px;justify-content:space-between;align-items:start;font-size:12px;color:var(--muted)}.reader-footer strong{font:23px var(--font-serif);color:var(--ink)}.reader-footer nav{display:flex;flex-wrap:wrap;gap:8px 20px;max-width:500px}.reader-footer a{color:#3e5c60}.reader-footer p{margin:8px 0;max-width:400px}.reader-toast{position:fixed;bottom:24px;left:calc(50% + 126px);transform:translateX(-50%);z-index:2000;background:var(--ink);color:white;padding:12px 20px;border-radius:5px;font-size:14px;box-shadow:0 8px 30px #102b3826;max-width:calc(100vw - 32px)}
.reader-dialog{background:var(--paper);color:var(--ink);border:1px solid #c7d3c9;border-radius:10px;box-shadow:0 24px 100px #001c4055;width:min(720px,calc(100vw - 32px));padding:0;max-height:85dvh}.reader-dialog::backdrop{background:#071f2bb3;backdrop-filter:blur(4px)}.reader-dialog-header{display:flex;align-items:center;justify-content:space-between;padding:20px 24px;border-bottom:1px solid var(--line);gap:16px}.reader-dialog-header h2{font:25px var(--font-serif);margin:0}.reader-dialog-close{width:44px;height:44px;flex-shrink:0;background:#fff;border:1px solid var(--line);border-radius:5px;color:var(--ink);font-size:22px}.reader-dialog-content{padding:24px}.reader-search-field{display:block;width:100%;border:1px solid #b6c9be;background:#fff;border-radius:5px;padding:14px 16px;font-size:18px;min-height:50px}.reader-search-status{color:var(--muted);font-size:13px;padding:12px 0;min-height:44px}.reader-search-results{display:grid;gap:8px;max-height:50dvh;overflow:auto}.reader-result{display:block;text-decoration:none;padding:15px 16px;background:white;border:1px solid var(--line);border-radius:5px;color:var(--ink)!important}.reader-result:hover{background:#eaf3eb;border-color:#96bbad}.reader-result small{display:block;font-size:12px;letter-spacing:1.1px;text-transform:uppercase;color:var(--accent)}.reader-result strong{font-size:17px;font-weight:600}.reader-result p{font-size:13px;line-height:1.6;color:var(--muted);margin:5px 0}.reader-result mark{background:#dae9aa;color:var(--ink)}.reader-shortcut-grid{display:grid;grid-template-columns:1fr auto;gap:12px;font-size:15px}.reader-shortcut-grid kbd{padding:1px 8px;border:1px solid #cbd7cd;border-radius:3px;background:white}.reader-image-dialog{width:min(1320px,calc(100vw - 24px));max-height:94dvh;background:#fff}.reader-image-dialog .reader-dialog-header{padding:10px 18px}.reader-image-stage{max-height:68dvh;overflow:auto;background:#ecf0e9;text-align:center;padding:20px}.reader-image-stage img{max-width:100%;width:auto;height:auto;max-height:62dvh;object-fit:contain;display:block;margin:auto}.reader-image-stage.zoomed{text-align:left}.reader-image-stage.zoomed img{max-width:none;max-height:none;width:1600px;margin:0}.reader-image-controls{display:flex;gap:8px;flex-wrap:wrap;align-items:center;padding:12px 20px;border-top:1px solid var(--line)}.reader-image-caption{padding:0 20px 18px;font-size:13px;line-height:1.6;color:var(--muted);margin:0}.reader-drawer-content{padding:24px;background:#102b38;color:white;min-height:100%}.reader-drawer-content .reader-chapters a{color:#d6e4e5}.reader-drawer-content .reader-brand{margin-bottom:20px}.reader-drawer-content .reader-dialog-close{float:right;background:#24434b;color:white;border:1px solid #47616a}.reader #consent-banner{background:#fff!important;border-top:1px solid var(--line)!important;box-shadow:0 -8px 30px #153d4010!important;z-index:100!important}.reader #consent-banner *{font-family:var(--font-sans)!important}.reader .consent-btn{border-radius:5px!important;min-height:44px!important}.reader .consent-btn-primary{background:var(--accent)!important}.reader .reader-mobile-outline{display:none}
@media(min-width:1700px){.reader-main{padding-top:48px}.reader-grid{gap:64px}.reader-masthead{gap:64px}}
@media(max-width:1280px){.reader-rail{width:220px;padding-left:14px;padding-right:14px}.reader-shell{margin-left:220px}.reader-grid{grid-template-columns:1fr}.reader-outline{display:none}.reader-masthead{gap:24px;grid-template-columns:minmax(0,1fr) 33%}.reader-title{font-size:42px!important}.reader-main{padding-left:32px;padding-right:32px}.reader-topbar{padding-left:32px;padding-right:32px}.reader-topbar-label{display:none}.reader-search-launch{min-width:260px}.reader-toast{left:calc(50% + 110px)}.reader .reader-mobile-outline{display:block;margin:0 0 24px;border:1px solid var(--line);padding:12px 16px;border-radius:5px}.reader-mobile-outline summary{font-size:14px;cursor:pointer;font-weight:600}.reader-mobile-outline nav{display:flex;gap:8px;flex-wrap:wrap;margin-top:12px}.reader-mobile-outline a{font-size:13px;border:1px solid var(--line);padding:6px 10px;border-radius:3px;text-decoration:none}}
@media(max-width:900px){.reader-rail{display:none}.reader-shell{margin-left:0}.reader-mobile-menu{display:inline-flex}.reader-topbar{height:68px;padding:0 24px}.reader-search-launch{min-width:0;flex:1;max-width:400px}.reader-preview-label{display:none}.reader-main{padding:28px 24px 64px}.reader-title{font-size:42px!important}.reader-masthead{grid-template-columns:1fr 34%}.reader-toast{left:50%}.reader-footer{padding:28px 24px}.reader-focus .reader-shell{margin-left:0}.reader-drawer{margin:0;width:min(340px,calc(100vw - 40px));height:100dvh;max-height:none;border-radius:0;border:0}}
@media(max-width:600px){body.reader{font-size:16px}.reader-main{padding:24px 18px 48px}.reader-topbar{padding:0 18px;gap:10px}.reader-topbar .reader-tool{padding:8px 10px}.reader-search-launch{font-size:13px;padding:8px 10px;min-height:44px}.reader-search-launch kbd{display:none}.reader-title{font-size:36px!important;letter-spacing:-1px;max-width:none}.reader-masthead{grid-template-columns:1fr;gap:24px;margin-bottom:18px;padding-bottom:26px}.reader-hero{min-height:190px;max-height:240px}.reader-hero img{height:220px;min-height:190px}.reader-deck{font-size:16px}.reader-byline{font-size:12px}.reader-tools{gap:6px}.reader-tool{font-size:12px;padding:8px 10px}.reader-time{width:100%;margin-left:0;margin-top:4px}.reader .reading-content h2,.reader .reading-content .section-title{font-size:28px!important}.reader .reading-content p,.reader .reading-content .body-text,.reader .reading-content .tc-text,.reader .reading-content .pc-text,.reader .reading-content .sc-text,.reader .reading-content .callout-text{font-size:16px!important}.reader .reading-content .tc-header,.reader .reading-content .pc-header,.reader .reading-content .dp-header,.reader .reading-content .tc-body,.reader .reading-content .pc-body,.reader .reading-content .dp-body{padding:18px!important}.reader .reading-content .tc-top{display:block!important}.reader .reading-content .tc-verdict{margin-top:14px;text-align:left!important}.reader .reading-content .outcomes-row,.reader .reading-content .stats-band,.reader .reading-content .pc-props{display:grid!important;grid-template-columns:1fr!important}.reader .reading-content .stat-item{border:0!important;padding:10px!important}.reader .reading-content .atlas-description,.reader .reading-content .atlas-figure-header{padding:18px!important}.reader .reading-content table{min-width:560px!important}.reader .reading-content td,.reader .reading-content th{padding:10px 12px!important}.reader .reading-content .pico-table{min-width:0!important}.reader .reading-content .diagram-box{max-width:100%}.reader-footer{display:block;padding:28px 18px}.reader-footer nav{margin-top:24px}.reader-dialog-header{padding:16px}.reader-dialog-content{padding:16px}.reader-dialog-header h2{font-size:22px}.reader-large .reading-content p,.reader-large .reading-content .tc-text{font-size:19px!important}}
@media(prefers-reduced-motion:reduce){.reader *{scroll-behavior:auto!important;animation:none!important;transition:none!important}}
@media print{.reader-rail,.reader-topbar,.reader-tools,.reader-outline,.reader-section-actions,.reader-disclosure,.reader-table-tools,.reader-footer,.reader-governance,.reader-mobile-outline,#consent-banner,.reader-dialog{display:none!important}.reader-shell{margin:0!important}.reader-main{padding:0!important;max-width:none!important}.reader-grid{display:block}.reader .reading-content [hidden]{display:block!important}.reader .reading-content .trial-card{break-inside:avoid}.reader .reading-content .section{border-bottom:1px solid #ddd!important}.reader-hero{max-height:200px}.reader a{color:#000;text-decoration:underline}.reader .reader-table-region{overflow:visible}.reader .reading-content table{font-size:12px!important}.reader{background:#fff!important}}

/* Isolate the new shell from legacy generic navigation and button selectors. */
body.reader .reader-chapters,body.reader .reader-outline nav,body.reader .reader-breadcrumb,body.reader .reader-footer nav,body.reader .reader-mobile-outline nav{background:transparent!important;box-shadow:none!important;border:0!important;position:static!important;height:auto!important;max-width:none!important;backdrop-filter:none!important}
body.reader .reader-chapters a{background:transparent!important;color:#d6e4e5!important}
body.reader .reader-chapters a:hover{background:#1b3b48!important}
body.reader .reader-chapters a[aria-current=page]{background:#244b51!important;color:#fff!important}
body.reader .reader-tool,body.reader .reader-search-launch,body.reader .reader-search-field,body.reader .reader-dialog button,body.reader .reader-dialog input{font-family:'Source Sans 3',sans-serif!important}
body.reader .reader-tool{font-size:13px!important}
body.reader .reader-topbar .reader-mobile-menu{display:none!important}
body.reader .prose-updated{font-size:13px!important;color:var(--muted);margin:0 0 20px}
body.reader .reader-search-results,body.reader .reader-saved-list{min-width:0}
@media(max-width:900px){body.reader .reader-topbar .reader-mobile-menu{display:inline-flex!important}}

body.reader .reading-content .tabs,body.reader .reading-content .tab-buttons,body.reader .reading-content .tab-nav{display:flex;flex-wrap:wrap;gap:6px;border-bottom:1px solid var(--line);padding-bottom:10px;margin:20px 0}
body.reader .reading-content .tab-btn{min-height:44px!important;padding:8px 14px!important;background:white!important;border:1px solid #c4d2c8!important;border-radius:4px!important;color:var(--ink)!important;font-size:14px!important}
body.reader .reading-content .tab-btn[aria-selected=true]{background:#e5f2ec!important;border-color:var(--accent)!important;color:var(--accent)!important}
@media(max-width:600px){body.reader .reader-search-wide{display:none}.reader-search-launch{white-space:nowrap}.reader-topbar .reader-tool{padding-left:9px;padding-right:9px}}
@media print{body.reader .reading-content .tab-panel{display:block!important}}

body.reader .reader-governance .governance-notice,body.reader .reader-governance .governance-notice p,body.reader .reader-governance .governance-notice a{font-size:13px!important;line-height:1.65!important}

/* Reading polish: scoped to inner routes; preserve the original landing styles. */
body.reader .reading-content .info-box{padding:20px 24px;margin:24px 0;border:1px solid var(--line);border-left:3px solid var(--accent);border-radius:7px;background:#f0f3ee;color:var(--ink);line-height:1.65}
body.reader .reader-update{padding:16px 20px;margin:24px 0;border-left:3px solid var(--accent);background:#f0f3ee;color:#233843;font-size:16px;line-height:1.65;border-radius:7px;max-width:72ch}
body.reader dialog.reader-dialog:not(.reader-drawer){margin:auto;inset:0}
body.reader{font-optical-sizing:auto}
body.reader .reader-tool{font-size:15px!important;line-height:1.4!important;min-height:44px}
body.reader .reader-search-launch{font-size:15px!important;line-height:1.4!important;min-height:44px}
body.reader .reader-hero button,body.reader .reader-section-actions button,body.reader .reader-disclosure{font-size:14px!important;line-height:1.4!important;min-height:44px}
body.reader .reading-content p,body.reader .reading-content li{max-inline-size:72ch;overflow-wrap:anywhere}
body.reader .reader-title,body.reader .reader-deck,body.reader .reader-result,body.reader .reader-byline{overflow-wrap:anywhere;min-width:0}
body.reader .reader-byline-mark{flex-shrink:0}
body.reader .reader-mobile-outline summary{min-height:44px;align-content:center}
body.reader .reader-mobile-outline a{min-height:44px;display:inline-flex;align-items:center}
body.reader.reader-large .reading-content p,body.reader.reader-large .reading-content li,body.reader.reader-large .reading-content .body-text,body.reader.reader-large .reading-content .tc-text,body.reader.reader-large .reading-content .pc-text,body.reader.reader-large .reading-content .sc-text,body.reader.reader-large .reading-content .callout-text{font-size:20px!important;line-height:1.75!important}
body.reader.reader-large .reading-content td,body.reader.reader-large .reading-content th{font-size:17px!important;line-height:1.65!important}
body.reader.reader-large .reading-content figcaption,body.reader.reader-large .reading-content .footnote{font-size:16px!important;line-height:1.65!important}
@media(max-width:600px){body.reader .reader-topbar{gap:8px;padding-inline:12px}body.reader .reader-topbar .reader-tool{padding-inline:8px}body.reader .reader-search-launch{padding-inline:8px;gap:6px}}
@media(forced-colors:active){body.reader :focus-visible{outline:3px solid Highlight!important}body.reader .reader-tool[aria-pressed=true],body.reader .reader-chapters a[aria-current=page]{border:2px solid Highlight!important}}