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var(--font-mono);margin-top:8px}.outcome-chart{border-top:1px solid var(--card-line);gap:7px;margin-top:16px;padding-top:13px;display:grid}.chart-row{grid-template-columns:70px minmax(0,1fr);align-items:center;gap:8px;display:grid}.chart-row span{color:var(--card-muted);font:600 9px/1 var(--font-mono);text-transform:uppercase}.chart-bar{width:var(--bar-size);background:linear-gradient(90deg,var(--card-blue),#4e9bd5);transform-origin:0;border-radius:999px;height:7px;animation:.65s both chart-grow;display:block}.chart-comparator{background:linear-gradient(90deg,#aab7c5,#75869a)}@keyframes chart-grow{0%{transform:scaleX(0)}to{transform:scaleX(1)}}.legacy-content .diagram-box,.legacy-content .callout,.legacy-content .key-fact,.legacy-content .drug-tabs{border-radius:16px}.legacy-content table:not(.pico-table){background:var(--card-surface)}@media (width<=980px){.page-layout{grid-template-columns:1fr}.sidebar-left{display:none}.main-content{max-width:none}.section.content-card 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(prefers-reduced-motion:reduce){.legacy-content .trial-card,.chart-bar{transition:none!important;animation:none!important}}.tone-blue{--tone:#1769aa;--tone-deep:#0c4c82;--tone-soft:#e8f4ff}.tone-teal{--tone:#07867b;--tone-deep:#04665f;--tone-soft:#e5faf6}.tone-amber{--tone:#c27814;--tone-deep:#8c5309;--tone-soft:#fff4dc}.tone-coral{--tone:#d6534d;--tone-deep:#a43732;--tone-soft:#ffebe8}.tone-violet{--tone:#7456b5;--tone-deep:#52368f;--tone-soft:#f0eaff}[data-theme=dark] .tone-blue{--tone:#82b9f2;--tone-deep:#c4ddf7;--tone-soft:#162c44}[data-theme=dark] .tone-teal{--tone:#5ed8cd;--tone-deep:#a6f0ea;--tone-soft:#123b38}[data-theme=dark] .tone-amber{--tone:#eab65d;--tone-deep:#ffe0a6;--tone-soft:#3a2c16}[data-theme=dark] .tone-coral{--tone:#ef8a82;--tone-deep:#ffc7c2;--tone-soft:#3d2325}[data-theme=dark] .tone-violet{--tone:#b9a5ef;--tone-deep:#e3dbff;--tone-soft:#2e2846}.legacy-content .section.content-card{background:linear-gradient(135deg,var(--tone-soft) 0,color-mix(in srgb,var(--tone-soft) 48%,var(--card-surface)) 18%,var(--card-surface) 48%)}.section.content-card:before{background:linear-gradient(180deg,var(--tone),var(--tone-deep));width:6px}.section.content-card .section-num,.section.content-card .section-title em{color:var(--tone-deep)}.section.content-card .section-title:after{content:"";background:linear-gradient(90deg,var(--tone),color-mix(in srgb,var(--tone) 15%,transparent));border-radius:999px;width:64px;height:4px;margin-top:14px;display:block}.section.content-card .section-toggle{border-color:color-mix(in srgb,var(--tone) 28%,var(--card-line));background:color-mix(in srgb,var(--tone-soft) 80%,var(--card-surface));color:var(--tone-deep)}.section.content-card .section-toggle b{color:var(--tone-deep);background:var(--card-surface)}.legacy-content .section.content-card .trial-card{border-color:color-mix(in srgb,var(--tone) 24%,var(--card-line));background:linear-gradient(135deg,var(--tone-soft),var(--card-soft) 60%)}.legacy-content .section.content-card .trial-card .tc-header{background:linear-gradient(135deg,color-mix(in srgb,var(--tone-soft) 88%,var(--card-surface)),var(--card-surface) 68%)}.trial-card .tc-name{color:var(--tone-deep)}.trial-card .tc-verdict{border-color:color-mix(in srgb,var(--tone) 30%,var(--card-line));background:color-mix(in srgb,var(--tone-soft) 86%,var(--card-surface))}.trial-card .tc-meta-item{border-color:color-mix(in srgb,var(--tone) 18%,var(--card-line));background:color-mix(in srgb,var(--tone-soft) 55%,var(--card-surface))}.trial-card .tc-text{border-left-color:var(--tone);background:linear-gradient(90deg,color-mix(in srgb,var(--tone-soft) 72%,var(--card-surface)),var(--card-surface) 36%)}.trial-card .trial-toggle{border-color:color-mix(in srgb,var(--tone) 30%,var(--card-line));color:var(--tone-deep)}.section.content-card .outcome-box{border-color:color-mix(in srgb,var(--tone) 22%,var(--card-line));background:linear-gradient(160deg,color-mix(in srgb,var(--tone-soft) 72%,var(--card-surface)),var(--card-surface) 62%)}.section.content-card .outcome-box:after{background:linear-gradient(90deg,var(--tone),var(--tone-deep));height:5px}.section.content-card .outcome-box:nth-child(2){--metric-accent:#07867b;--metric-soft:#e5faf6;background:linear-gradient(160deg,var(--metric-soft),var(--card-surface) 62%)}.section.content-card .outcome-box:nth-child(2):after{background:linear-gradient(90deg,#07867b,#04665f)}.section.content-card .outcome-box:nth-child(3){--metric-accent:#c27814;--metric-soft:#fff4dc;background:linear-gradient(160deg,var(--metric-soft),var(--card-surface) 62%)}.section.content-card .outcome-box:nth-child(3):after{background:linear-gradient(90deg,#c27814,#8c5309)}.section.content-card .chart-primary{background:linear-gradient(90deg,var(--tone),color-mix(in srgb,var(--tone) 68%,#fff))}.section.content-card .chart-comparator{background:linear-gradient(90deg,color-mix(in srgb,var(--tone) 30%,#9aa8b8),#8595a8)}.legacy-content .drug-profile{border:1px solid color-mix(in srgb,var(--tone) 28%,var(--card-line));background:var(--card-surface);border-radius:20px;margin:20px 0;transition:transform .2s,box-shadow .2s;position:relative;overflow:hidden;box-shadow:0 12px 34px #10233a14}.legacy-content .drug-profile:hover{transform:translateY(-2px);box-shadow:0 19px 46px #10233a1f}.drug-profile .dp-header{background:linear-gradient(135deg,var(--tone-soft),color-mix(in srgb,var(--tone-soft) 35%,var(--card-surface)) 72%);border-bottom:1px solid color-mix(in srgb,var(--tone) 18%,var(--card-line));grid-template-columns:58px minmax(0,1fr) auto;align-items:center;gap:16px;padding:22px 22px 20px;display:grid;position:relative}.drug-profile:not(.is-open) .dp-header{border-bottom:0}.drug-profile .dp-generation{border:1px solid color-mix(in srgb,var(--tone) 24%,transparent);width:54px;height:54px;box-shadow:inset 0 0 0 5px color-mix(in srgb,var(--card-surface) 45%,transparent);place-items:center;font-size:25px;display:grid;background:color-mix(in srgb,var(--tone-soft) 76%,var(--card-surface))!important;border-radius:17px!important}.drug-profile .dp-name{color:var(--tone-deep);font:700 clamp(1.35rem,2.5vw,1.85rem)/1.05 var(--font-display);letter-spacing:-.02em}.drug-profile .dp-brands{color:var(--card-muted);margin-top:5px;font-size:12px;line-height:1.5}.drug-profile .dp-tags{flex-wrap:wrap;gap:6px;margin-top:10px;display:flex}.drug-profile .dp-tag{min-height:24px;font:700 9px/1 var(--font-mono);letter-spacing:.03em;align-items:center;padding:5px 9px;display:inline-flex;border-radius:999px!important}.drug-toggle{border:1px solid color-mix(in srgb,var(--tone) 32%,var(--card-line));background:var(--card-surface);min-height:40px;color:var(--tone-deep);font:700 10px/1 var(--font-body);letter-spacing:.04em;cursor:pointer;border-radius:999px;justify-content:center;align-items:center;gap:8px;padding:0 12px;display:inline-flex}.drug-toggle b{background:var(--tone-soft);width:20px;height:20px;color:var(--tone-deep);border-radius:50%;place-items:center;font-size:15px;display:grid}.drug-toggle:hover{background:var(--tone-soft)}.drug-toggle:focus-visible{outline:3px solid color-mix(in srgb,var(--tone) 36%,transparent);outline-offset:3px}.drug-profile .dp-body{background:linear-gradient(180deg,var(--card-surface),color-mix(in srgb,var(--tone-soft) 20%,var(--card-surface)));padding:22px}.drug-profile .dp-body[hidden],.drug-profile .dp-footer[hidden]{display:none}.drug-profile .dp-props{grid-template-columns:repeat(4,minmax(0,1fr));gap:10px;margin-bottom:24px;display:grid}.drug-profile .dp-prop{border:1px solid color-mix(in srgb,var(--tone) 19%,var(--card-line));background:color-mix(in srgb,var(--tone-soft) 55%,var(--card-surface));border-radius:13px;min-width:0;padding:13px 14px}.drug-profile .dp-prop-label{color:var(--tone-deep);font:800 9px/1.25 var(--font-mono);letter-spacing:.06em;text-transform:uppercase}.drug-profile .dp-prop-val{color:var(--card-ink);margin-top:6px;font-size:12px;font-weight:650;line-height:1.45}.drug-profile .dp-section-label{color:var(--tone-deep);font:800 10px/1.3 var(--font-mono);letter-spacing:.08em;text-transform:uppercase;align-items:center;gap:9px;margin:23px 0 9px;display:flex}.drug-profile .dp-section-label:before{content:"";background:var(--tone);width:8px;height:8px;box-shadow:0 0 0 4px var(--tone-soft);border-radius:50%}.drug-profile .dp-section-label:after{content:"";background:linear-gradient(90deg,color-mix(in srgb,var(--tone) 35%,var(--card-line)),transparent);flex:1;height:1px}.drug-profile .dp-text{border-left:3px solid var(--tone);background:var(--card-surface);max-width:88ch;color:var(--card-muted);border-radius:0 12px 12px 0;padding:15px 17px;font-size:13px;line-height:1.7}.drug-profile .dp-text strong{color:var(--card-ink)}.drug-profile .dp-evidence-row{grid-template-columns:repeat(auto-fit,minmax(180px,1fr));gap:11px;margin:10px 0 4px;display:grid}.drug-profile .dp-trial{border:1px solid color-mix(in srgb,var(--tone) 23%,var(--card-line));background:linear-gradient(150deg,var(--tone-soft),var(--card-surface) 66%);border-radius:14px;min-height:118px;padding:16px;position:relative;overflow:hidden}.drug-profile .dp-trial:before{content:"";background:linear-gradient(180deg,var(--tone),var(--tone-deep));width:4px;position:absolute;inset:0 auto 0 0}.drug-profile .dp-trial-name{color:var(--tone-deep);font:800 10px/1.2 var(--font-mono);letter-spacing:.05em;text-transform:uppercase}.drug-profile .dp-trial-result{color:var(--card-ink);font:700 1.05rem/1.25 var(--font-display);margin-top:13px}.drug-profile .dp-trial-detail{color:var(--card-muted);margin-top:6px;font-size:10px;line-height:1.45}.drug-profile .dp-footer{border-top:1px solid color-mix(in srgb,var(--tone) 18%,var(--card-line));background:linear-gradient(90deg,var(--tone-soft),var(--card-surface));color:var(--card-muted);flex-wrap:wrap;justify-content:space-between;align-items:center;gap:10px;padding:13px 22px;font-size:10px;line-height:1.45;display:flex}.drug-profile .dp-status{color:var(--card-ink);align-items:center;gap:7px;font-weight:800;display:inline-flex}.drug-profile .dp-status-dot{border-radius:50%;width:8px;height:8px}.legacy-content .gen-band{border:1px solid color-mix(in srgb,var(--tone) 18%,var(--card-line));background:linear-gradient(120deg,color-mix(in srgb,var(--tone-soft) 66%,var(--card-surface)),var(--card-surface));border-radius:14px;grid-template-columns:54px minmax(0,1fr) 88px;align-items:center;gap:16px;margin:9px 0;padding:15px 16px;display:grid;box-shadow:0 6px 18px #10233a0b}.gen-band .gen-num{width:46px;height:46px;font:700 1.15rem/1 var(--font-display);border-radius:14px;place-items:center;display:grid;background:var(--tone)!important;color:#fff!important}.gen-band .gen-title{color:var(--card-ink);font-weight:750;line-height:1.4}.gen-band .gen-desc{color:var(--card-muted);margin-top:4px;font-size:11px;line-height:1.5}.gen-band .gen-count{text-align:center;background:var(--card-surface);border:1px solid var(--card-line);border-radius:10px;padding:8px}.gen-band .gen-count-num{color:var(--tone-deep);font:700 1.25rem/1 var(--font-display)}.gen-band .gen-count-label{color:var(--card-muted);text-transform:uppercase;letter-spacing:.06em;margin-top:4px;font-size:8px}.legacy-content .timeline{gap:12px;margin-top:20px;display:grid;position:relative}.legacy-content .timeline:before{content:"";background:linear-gradient(180deg,var(--tone),color-mix(in srgb,var(--tone) 16%,var(--card-line)));width:2px;position:absolute;top:25px;bottom:25px;left:20px}.timeline .tl-item{grid-template-columns:42px minmax(0,1fr);align-items:start;gap:13px;display:grid;position:relative}.timeline .tl-marker{z-index:1;place-items:center;min-height:44px;display:grid}.timeline .tl-dot{border:4px solid var(--card-surface);width:15px;height:15px;box-shadow:0 0 0 2px color-mix(in srgb,var(--tone) 30%,var(--card-line));background:currentColor;border-radius:50%}.timeline .tl-body{border:1px solid color-mix(in srgb,var(--tone) 18%,var(--card-line));background:linear-gradient(135deg,color-mix(in srgb,var(--tone-soft) 44%,var(--card-surface)),var(--card-surface) 70%);border-radius:13px;padding:14px 16px}.timeline .tl-year{font:800 9px/1.3 var(--font-mono);letter-spacing:.06em;text-transform:uppercase}.timeline .tl-drug{color:var(--card-ink);margin-top:5px;font-weight:800;line-height:1.4}.timeline .tl-detail{color:var(--card-muted);margin-top:5px;font-size:11px;line-height:1.55}@media (width<=820px){.drug-profile .dp-props{grid-template-columns:repeat(2,minmax(0,1fr))}.drug-profile .dp-header{grid-template-columns:48px minmax(0,1fr)}.drug-profile .dp-generation{width:46px;height:46px}.drug-profile .drug-toggle{grid-column:1/-1;justify-self:start}.legacy-content .gen-band{grid-template-columns:46px minmax(0,1fr)}.gen-band .gen-count{text-align:left;grid-column:2;align-items:baseline;gap:7px;display:flex}}@media (width<=520px){.drug-profile .dp-body{padding:16px}.drug-profile .dp-props{grid-template-columns:1fr 1fr;gap:8px}.drug-profile .dp-evidence-row{grid-template-columns:1fr}.drug-profile .dp-footer{padding:13px 16px}.legacy-content .gen-band{padding:13px 12px}.timeline .tl-body{padding:13px}.timeline .tl-item{grid-template-columns:34px minmax(0,1fr)}.legacy-content .timeline:before{left:16px}}@media (prefers-reduced-motion:reduce){.legacy-content .drug-profile{transition:none}}.panel-toggle{border:1px solid color-mix(in srgb,var(--tone) 30%,var(--card-line));background:var(--card-surface);min-height:38px;box-shadow:0 5px 14px color-mix(in srgb,var(--tone) 10%,transparent);color:var(--tone-deep);font:800 9px/1 var(--font-body);letter-spacing:.04em;cursor:pointer;white-space:nowrap;border-radius:999px;justify-content:center;justify-self:end;align-items:center;gap:8px;padding:0 10px 0 13px;display:inline-flex}.panel-toggle span{min-width:0}.panel-toggle b{background:var(--tone-soft);border-radius:50%;flex:0 0 19px;place-items:center;width:19px;height:19px;font-size:14px;display:grid}.panel-toggle:hover{background:var(--tone-soft)}.panel-toggle:focus-visible{outline:3px solid color-mix(in srgb,var(--tone) 36%,transparent);outline-offset:3px}.legacy-content .clinical-panel{border:1px solid color-mix(in srgb,var(--tone) 24%,var(--card-line));background:var(--card-surface);border-radius:18px;margin:16px 0;transition:transform .2s,box-shadow .2s;position:relative;overflow:hidden;box-shadow:0 10px 30px #10233a12}.legacy-content .clinical-panel:hover{transform:translateY(-2px);box-shadow:0 17px 42px #10233a1c}.clinical-panel [hidden]{display:none!important}.legacy-content .guideline-header{border:1px solid var(--card-line);background:var(--card-surface);border-radius:19px;margin:20px 0;overflow:hidden;box-shadow:0 12px 34px #10233a14}.guideline-header .gh-banner{height:7px}.guideline-header .gh-body{grid-template-columns:48px minmax(0,1fr) auto;align-items:start;gap:16px;padding:22px;display:grid}.guideline-header .gh-flag{background:var(--card-soft);border-radius:14px;place-items:center;width:46px;height:46px;font-size:24px;display:grid}.guideline-header .gh-org{color:var(--card-blue);font:800 9px/1.35 var(--font-mono);letter-spacing:.07em;text-transform:uppercase}.guideline-header .gh-title{color:var(--card-ink);font:700 1.35rem/1.2 var(--font-display);margin-top:7px}.guideline-header .gh-meta{flex-wrap:wrap;gap:6px;margin-top:10px;display:flex}.guideline-header .gh-chip{font:700 9px/1 var(--font-mono);border-radius:999px;padding:5px 8px}.guideline-header .gh-scope{max-width:80ch;color:var(--card-muted);margin-top:13px;font-size:12px;line-height:1.65}.guideline-header .gh-actions{text-align:right}.guideline-header .gh-year{color:var(--card-ink);font:700 1.8rem/1 var(--font-display)}.guideline-header .gh-link{color:var(--card-blue);margin-top:10px;font-size:10px;font-weight:800;display:inline-block}.legacy-content .rec-group{margin:22px 0}.rec-group .rec-group-title{font:800 10px/1.4 var(--font-mono);letter-spacing:.06em;text-transform:uppercase;align-items:center;gap:9px;margin:0 0 10px;display:flex}.rec-card .rec-card-header{background:linear-gradient(135deg,var(--tone-soft),var(--card-surface) 72%);grid-template-columns:48px minmax(0,1fr) auto;align-items:center;gap:15px;padding:17px 18px;display:grid}.rec-card .rec-grade{min-height:40px;font:800 12px/1 var(--font-mono);border-radius:12px;place-items:center;display:grid}.rec-card .rec-label{font:800 9px/1.35 var(--font-mono);letter-spacing:.06em;text-transform:uppercase}.rec-card 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